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KMID : 0372919920130010055
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Journal of Biomedical Engineering Research
1992 Volume.13 No. 1 p.55 ~ p.64
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Synthesis of Block Copolymers consisting of Poly (γ-benzyl L-glutamate) and Polyoxpropylene and Their Drug Release Behaviours
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강인규
김우식/권대룡/최영윤/김교한
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Abstract
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AB -type block copolymers of poly(T -benzyl L -glutamate) (PBLG, a segment) and polyoxypropylene (POP, Bsegment) were synthesized and they were reacted with polyoxypropylene his(6-aminohexyl) (POE) to enhance the hydrophilicity of the poly- mers. The degree of swelling of the POE -crosslinked block copolymers (CPB -2) was higher than that of the block dopolymers (PB). The amount of 5-fluorouracil re- leased from CPB-2 block copolymers was greater than that from the PB block copol- ymers when they were incubated in the same period. These results indicate that the amount of 5-fluorouracil released from the matrices is proportional to the hydrophilicity of the polymers. Observing polymer surfaces by scanning electron mi- croscope, pores (diameter : 0.5-1.5um) were appeared on the surface of CPB-2
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